Comparison of Enzyme Immunoassay with Gas-liquid Chromatography in Phenytoin Determination
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چکیده
منابع مشابه
Comparative determination of phenytoin by spectrophotometry, gas chromatography, liquid chromatography, enzyme immunoassay, and radioimmunoassay.
Sera from patients being treated with phenytoin were analyzed for the drug by spectrophotometry, gas chromatography, radioimmunoassay, enzyme immunoassay, and liquid chromatography. The essay values obtained were intercompared statistically. Enzyme immunoassay and liquid chromatography appear to be attractive alternatives to the more traditional methods of spectrophotometry and gas chromatograp...
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Lidocaine, an anti-arrhythmic drug, was quantitated in serum by a commercially supplied enzyme immunoassay procedure. Replicate analyses of serum controls resulted in a within-assay coefficient of variation of less than 5.0 and a between-assay coefficient of variation of less than 6.5. Regression analysis of 87 serum samples analyzed by this technique (y) and by gas-liquid chromatography (x) g...
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Patients' sera were analyzed for carbamazepine and ethosuximide by enzyme immunoassay (x) and gas chromatography (y), and the results were compared. The correlation coefficients were: for carbamazepine, x vs. y 0.94 (n = 93); for ethosuximide, x vs. y 0.99 (n = 30). These results suggest that the two methods could be used interchangeably. Ten serum samples supplemented with carbamazepine (2.5 t...
متن کاملResults by fluorescent immunoassay for phenytoin compared with those by enzyme immunoassay, liquid chromatography, and discrete analysis (Dupont aca).
We describe the Ames Fluorescent Enzyme Immunoassay procedure for the detection of phenytoin in serum, and compare the results with it with those by enzyme immunoassay(EMIT), "high-pressure" liquid chromatography, and the Dupont aca. Sera from 48 patients who were receiving phenytoin were promptly analyzed in duplicate by EMIT, frozen, then assayed within four weeks by the other three methods. ...
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ژورنال
عنوان ژورنال: Japanese Journal of Hospital Pharmacy
سال: 1979
ISSN: 2185-9477,0389-9098
DOI: 10.5649/jjphcs1975.5.141